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However, AngIV and most of its analogs have a short half-life and cannot cross the bloodbrain barrier (BBB), limiting their use in animal models

The results showed that ADMSCs in the co-culture system differentially expressed 360 lncRNAs and 1757 mRNAs, had 589 up-regulated genes and 661 down-regulated genes, and showed changes in 299 signalling pathways (Table 4)

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Where thymalin is a complex extract, vilon is a defined dipeptide (Lys-Glu) identified by Khavinson's group as the shortest sequence capable of reproducing thymalin's core immunomodulatory effects
