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Metabolic reprogramming, which includes changes in the activity of fatty acid oxidation (FAO), tricarboxylic acid (TCA) cycle, glycolysis levels, involvement of pentose phosphate pathway and mitochondrial respiration mediates the phenotypical and functional role of myeloid cells

The therapeutic effect depends on the degree of immune cell infiltration within the tumor tissue, with cancers classified as hot tumors or cold tumors based on immune cell infiltration in the tumor microenvironment

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Other viral pathogens that promote asthma exacerbations are influenza viruses [421], but, surprisingly, not COVID-19, as ICS administered in regular asthma treatment seem to protect against the disease and asthmatic patients are less prone to COVID-19 [422,423,424,425]