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The pKa of a drug influences solubility, lipophilicity, protein binding and permeability and is of paramount importance to the overall characteristics of a drug [56]

Fila C, Metz C, Van Der Sluijs P

[2] [4] Another metabolic advantage, similar to multifunctional enzymes, is that multienzyme complexes allow coordinated regulation of the catalytic activity of their constituent enzymes

Ceppi P, Mudduluru G, Kumarswamy R, Rapa I, Scagliotti GV, Papotti M, Allgayer H

To determine whether either hepatokine plays a predominant role, we performed GTT and ITT analyses following individual knockdown of fetuin-A or LECT2

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