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Adult cartilage shows declining cellularity, accumulated matrix damage, reduced proteoglycan content, calcification advancement

However, significant heterogeneity in study design, measures of inflammatory biomarkers and analysis techniques 193 , makes evaluation of inflammatory markers compared to other markers of progression in PD difficult, and their clinical usefulness remains uncertain

DOI:10.1186/1471-2180-10-323 124

Even though my GP says the reason I cannot self-administer is because the surgery is monitoring my long-term chronic condition