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Diabetologia 56 (3), 563572

These results indicate that an improvement of the drug-delivery system is necessary for treatment with NAC

An advantage of using a hydrazide-activated support is that no reducing agent is needed to stabilize the linkage between the ligand and support, as is required in reductive amination

FIN56, another specific ferroptosis inducer, triggers ferroptosis by promoting the degradation of GPX4 via the acetyl-CoA pathway (Sun et al., 2021

SASP in disease-associated glial and immune cells Although senescent cells have ceased dividing, they are far from being completely silent. On the contrary, they remain metabolically and transcriptionally active, actively secreting proinflammatory molecules

These studies highlight the therapeutic potential of targeting metabolic enzymes, metabolites, and inflammatory signaling hubs to reprogram macrophage metabolism and polarization phenotypes
