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Most recently, a self-assembled pH-sensitive superparamagnetic iron oxide nanoclusters (SPIONCs) is reported to enhance in situ ferroptosis and apoptosis of lung tumors with radiotherapy and chemodynamic therapy via releasing iron in the tumor microenvironment (TME) [118]
Folate is trapped as methyltetrahydrofolate and therefore cannot serve as a substrate for thymidine synthesis
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