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Front Pharmacol (2020) 11:1021

doi: 10.1089/ars.2009.287 320 SankarPGopal TelangAKalaivananRKarunakaranVManikamKSarkarSN

Free radicals play critical role in generating oxidative stress, which oxidizes dopamine to dopamine quinone and superoxide anion and decreases the NADPH and dopamine metabolized by MOA that produces the 3,4-dihydroxyphenylacetaldehyde, ammonia, and H 2 O 2 , which in turn interacts with Fe ++ to generates the OH free radicals that kill neurons in PD [61, 62]

Patients with high ER and PR expression demonstrate higher response rates to hormone therapy and achieve more significant tumor shrinkage