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As such, secretory trafficking not only plays a role in synaptic function, but it also underlies neuronal differentiation and spine morphogenesis, with previous studies demonstrating that the manipulation of proteins involved in regulated secretory trafficking [11, 28, 29] or manipulations that block secretory trafficking [30] result in decreased dendritic outgrowth and impaired neuronal differentiation and spine morphogenesis

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The intestinal epithelial barrier: a therapeutic target
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