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GHSR-1a activation stimulates pulsatile GH release from pituitary somatotrophs via Gq/11-mediated phospholipase C activation and intracellular calcium mobilisation, as well as Gi-mediated cAMP modulation

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This can lead to increased GH levels, which is beneficial for various physiological processes such as muscle growth, fat metabolism, and overall body composition [2]

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Transforming growth factor-1 (TGF-1) can induce the EMT phenotype in melanoma cells and upregulate the levels of GPX4 and SLC7A11, while gambogenic acid, a xanthone derived from traditional Chinese medicine Gamboge, can promote ferroptosis by inhibiting the SLC7A11/GPX4 pathway in melanoma cells stimulated by TGF-1