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Lu P, Wang Y, Graham L, McHale K, Gao M, Wu D, et al

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Neuroinflammation is a common underlying factor in many neurodegenerative diseases and cognitive disorders

Subsequent studies compared the efficacy of different doses of apatinib on the survival of patients with advanced GC, and the results showed that compared with higher daily doses (675-850mg) of apatinib, lower daily doses (250-500 mg) of apatinib can achieve comparable outcomes in mOS and mPFS while maintaining more benign safety profile (99, 103, 104) in patients with GC