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However, some people with TMAU as defined by the choline challenge test do not have any variants, either rare ones with total loss of function or common ones (associated with less extreme impairment) in this gene

[DOI] [PubMed] [Google Scholar] Brousseau ME, Clairmont KB, Spraggon G, Flyer AN, Golosov AA, Grosche P, Amin J, Andre J, Burdick D, Caplan S, Chen G, Chopra R, Ames L, Dubiel D, Fan L, Gattlen R, Kelly-Sullivan D, Koch AW, Lewis I, Li J, Liu E, Lubicka D, Marzinzik A, Nakajima K, Nettleton D, Ottl J, Pan M, Patel T, Perry L, Pickett S, Poirier J, Reid PC, Pelle X, Seepersaud M, Subramanian V, Vera V, Xu M, Yang L, Yang Q, Yu J, Zhu G, Monovich LG, 2022

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OXIDATIVE STRESS AND ANTIOXIDANTs - an introduction to their relationship with male fertility potential Oxidative stress is an important contributor to male infertility problems