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Furthermore, the free DBP, DBP-Lip and DBP-Lip-Gel rescued the cells from UVB-induced death, showing cell viabilities 6.2 times, 7.1 times and 6.5 times, respectively, that of UVB-induced cells (Fig

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Additional MS/CPZ-specific downregulated genes further support broad impairment of OL function, including the neuregulin co-receptor ERBB3 (OL survival and differentiation), the citrullinating enzyme PADI2 (myelin basic protein post-translational modification), lipid biosynthesis genes ST3GAL5 and LPCAT2 , the pro-survival receptor LPAR1 , and the differentiation-associated transcription factor E2F3

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Metformin, alone or combined with cisplatin, downregulates NRF2 to counteract chemoresistance, while MSU38225, DHT, and Baicalin suppress NRF2 activity to disrupt redox adaptation in tumors
