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Description
Studies have indicated that TS is likely related to prior streptococcal infections [20, 21]

It is caused by the accumulation of misfolded or unfolded proteins in the ER lumen, resulting in overexpression of ER stress markers such as growth arrest and DNA damage-inducible protein 153 (CCAAT/enhancer binding protein homologous protein), glucose-regulated protein 78 (GRP78), and C/-EBP homologous protein (CHOP)
Further evidence of purine metabolism dysregulation comes from a study by McGregor et al

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