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The actual problem is often B12 deficiency that oral supplements cant fix

Deoxycholic acid (DCA), a secondary BA, inhibits the plasma membrane Ca + ATPase (PMCA), suppressing Ca + -NFAT2 signaling and reducing cytotoxic molecules such as IFN-, TNF-, and granzyme B (GzmB), potentially impairing ICI efficacy when intratumoral DCA is high (64, 67)

The antioxidant capacity of sulfur-containing amino acids, such as cysteine, contributes to their ability to neutralize reactive oxygen species (ROS) (Stipanuk, 2020)

In addition to its direct ability to neutralize ROS (like O 2 H, O 2 - , OH, etc.), H 2 S also enhances the expression of antioxidant enzymes, for example, glutathione peroxidase (GSH-Px) or superoxide dismutase (SOD), through nuclear factor erythroid-derived 2 (Nrf2) activation and translocation, which regulates the expression of antioxidant proteins (79)

Vitamins and minerals are important, but when they are taken by mouth the amount that can actually be absorbed and used is limited as they move through the intestines and are processed by the liver

Fathizadeh H, Milajerdi A, Reiner , Amirani E, Asemi Z, Mansournia MA, Hallajzadeh J (2020) The effects of L-carnitine supplementation on indicators of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials