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Thus, as summarized in Table 1 , the potential crossing route exploited seems to be dependent on the meningococcal strain, with strains belonging to cc32 and cc22 more likely to follow the transcellular route, while those belonging to cc11 more likely to follow the paracellular route

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However, in neuropathological situations, APP is metabolized by the amyloidogenic pathway in which the amyloid cleaving enzyme 1 (BACE 1