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Machado, Vanderlei G.Journal of the Brazilian Chemical Society (2012), 23 (8), 1488-1500CODEN: JOCSET

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Neuropathological investigations in the substantia nigra pars compacta of Parkinsons disease patients demonstrate that deficient PGC-1 expression compromises mitochondrial biogenesis and disrupts the coordinated transcriptional activation of antioxidant stress-responsive gene networks, thereby precipitating dopaminergic neuronal degeneration (Piccinin et al., 2021)