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Because most peoples gut bacteria cannot produce it efficiently, supplementing is the more reliable route

doi: 10.1111/jipb.12032 121 WangY.LoakeG.ChuC

[DOI] [PubMed] [Google Scholar] 2.Richards MJ, Edwards JR, Culver DH, and Gaynes RP 1999

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Proanthocyanidins/bioflavonoids are a class of naturally-occurring, water-soluble polyphenolic compounds that are found in plants

Researchers should note that AOD-9604 completed Phase II clinical trials under the pharmaceutical development programme of Metabolic Pharmaceuticals before the programme was discontinued