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FIGURE 2 On the other hand, in addition to its well-known functions, PGC1, a master regulator of mitochondrial biogenesis, positively regulates mitophagy by directly inducing the expression of transcription factor EB (TFEB) that mediates lysosomal biogenesis (Settembre et al., 2011)

Tudor et al., 2010) or less severe behavioral disturbances (Jelovac et al., 1998, 1999

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doi: 10.1089/ars.2006.8.354

At lower content of selenium, the ratio of GSH to GSSG did not increase significantly, probably due to the adaptive increase in GSH, which was an attempt to maintain the normal level of GSH to GSSG in the yeast cellular cytosol