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However, B12 levels can rise regardless of whether treatment is effective

A 2-unit error on a 10-unit dose is a 20% difference

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brains and bipolar disorder in particular are incredibly complicated and is a lot of evidence which you can easily find yourself showing that generally bipolar brains including the brains of people with recurrent mania suffer from under methylation in which case encouraging methylation with methyl B12 will be an overall helpful treatment in my practice I generally do prescribe methyl B12 to my bipolar patients but I never ever give any remedy but has potential antidepressant effects to someone with bipolar without also giving them mood stabilising or counterbalancing antimanic remedies

Curcumin: a natural substance with potential efficacy in Alzheimer's disease