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These intermediates are stabilized through H-bonds between their ribosyl 2-, 3- OH groups and the catalytic residue Glu226, a residue required for the NADase and cyclase activity of the enzyme [38-40, 58-60]
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High homocysteine levels can also be caused by low vitamin B12 levels because vitamin B12 is the cofactor needed by the enzyme responsible for converting homocysteine to methionine
