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High body mass index and low adiponectin levels are associated with reduced HCV-specific T cell responses 172 , increased liver injury 173 and poor virologic response to immune-based therapies 174

Knocking-in uses the same technique of homologous recombination as a knockout strategy, but the targeting vector is designed to preserve or enhance the function and control of the gene of interest, rather than disrupt it

Analysis of immune microenvironment components reveals that PC stage is associated with M2 macrophages, the marker gene of which is significantly correlated with GPX2

doi: 10.1186/s13045-021-01200-4 61 LiJDeNicolaGMRuffellB

Sarkaria IS, Biro TG, Singhal S, Reddy RM, Martin LW, Rice DC , Lopez AS, Stevens G, Barret T, Murthy SC

The internalization and release of iron and its reduction to the ferrous state within the cell involves intracellular ascorbic acid