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collateral pathways (i.e., left ovarian vein [20], inferior mesenteric vein [25], azygos vein [26]), reliant on the injurious occlusion, reestablished blood flow that compensated the vessel occlusion [20,21,22,23,24,25,26,27]

[1] In experimental models, the peptide appears to influence several pathways involved in healing: angiogenesis, fibroblast migration, collagen organization, nitric oxide signaling, extracellular matrix formation, and reducing inflammatory cytokines

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Because of the separating mechanism, pH, buffer type, buffer concentration, and temperature all play important roles in controlling the separation

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