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Moreover, a study of NOX2-deficient mice demonstrated that the absence of ROS prevents resistance to autoimmune arthritis

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3], and a number of studies have demonstrate that the oligomeric form of A is highly toxic and associated with oxidative stress [4

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Chemaly 1 1 UT MD Anderson Cancer Center, Houston, United States of America (the), 2 Memorial Sloan Kettering, New York, United States of America (the), 3 Cincinnati Childrens Hospital Medical Center, Cincinnati, United States of America (the), 4 University of Nebraska Medical Center, Omaha, United States of America (the), 5 Duke University Medical Center, Durham, United States of America (the), 6 Childrens Hospital of Philadelphia, Philadelphia, United States of America (the), 7 St