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While this is promising for advancing our knowledge on the benefits of nutrient synergy, these studies cannot indicate which constituents of the whole food are driving the health benefit

& Grant, S

Elevated levels of oxidative stress can potentially modify lipid, protein, and DNA, leading to inflammatory responses and apoptosis

The active metabolites of Pycnogenol, particularly the smaller phenolic acids and the gut-derived metabolite M1, can enter the central nervous system

doi: 10.1177/1744806918819944 38 TianXZhangLQianXPengYChenFBengtsonSet al

More recently [97], it was found that such adducts are also formed in vivo under chronic high-stress conditions (and, presumably, if a patient were treated with epinephrine pharmacologically)
