glutathione and cancer riskbmj CD47: an immunoregulatory nexus in liver gastrointestinal disorders Frontiers | Carcinogen metabolism and

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329,330 In degenerative joint diseases like OA, the metabolic balance of chondrocytes is disrupted, leading to the overproduction of degrading enzymes and inflammatory mediators, including iNOS, MMP-13, and ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), which participate in cartilage degradation and inflammatory processes

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the pentose-phosphate pathway and the synthesis of aromatic amino acids both rely on such enzymes, and these pathways fail during stress (Anjem and Imlay, 2012)

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