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Increased levels of Irisin (1 mg/kg/day, 5 days/week, 2 weeks) could significantly mitigate ROS accumulation, dysregulation of autophagy, NF-B-Snail pathway activation, and the phenotype of endothelial-to-mesenchymal transition through targeting UCP2 in a mouse DIC model [140]

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A Narrative Review of the Evidence for Variations in Serum 25-Hydroxyvitamin D Concentration Thresholds for Optimal Health

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doi: 10.1378/chest.13-1766 151 TaimehZHertzMIShumwaySPritzkerM

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3.1 Mitochondria-associated metabolic reprogramming of macrophages Mitochondria serve as the central hub for macrophage metabolic plasticity, which plays an important role in energy production, immune regulation, signal transduction, and cell fate determination, intervening the inflammation regulation and macrophage repair ( 1 % ( 3.1.1 ROS and oxidative stress Chronic exposure to cigarette smoke extracts (CSE) or particulate matter resulted in elevated oxidative stress, a critical metabolic characteristic in AMs of COPD patients ( Subsequent research indicated that AMs from COPD patients exhibited impaired phagocytosis associated with mitochondrial dysfunction ( 2 O 2 and hydroxyl radicalsOH)

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