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In the identification of unknown compounds, the use of high-resolution hybrid quadrupole (Q)-TOF, additionally coupled with high performance liquid chromatography (LC-QTOF-MS/MS) is irreplaceable (Rebiere et al., 2017)

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doi: 10.1210/jcem.78.1.7507118 101 EnglishKChikaniVDimeskiGInderWJ

Albumin levels are low in many disease states, resulting in lower total drug concentrations