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Toxic elements unfortunately build up over time in soft tissues and bone, and even when the external source is removed the bioaccumulated toxic elements represent an ongoing endogenous source of exposure, and measures to enhance excretion may be helpful

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The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase

This timeframe is restrictive because, in the immediate post-ESS period, the most crucial factor for continued improvement is likely the cleansing of nasal passages and the removal of crusts to prevent scarring

Aquac Res 50:28562866 Zhang X, Ma Y, Xiao J, Zhong H, Guo Z, Zhou C, Li M, Tang Z, Huang K, Liu T (2021) Effects of vitamin E on the reproductive performance of female and male Nile tilapia ( Oreochromis niloticus ) at the physiological and molecular levels