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199 Activated Akt promotes the expression and translocation of GLUT4 (Glucose Transporter Type 4) to the cell membrane, increasing cellular glucose uptake

& Ohman, D.E

doi: 10.1021/acsmedchemlett.8b00106 [DOI] [PMC free article] [PubMed] [Google Scholar] 344

In summary, the reactivity of glutathione (GSH) is a crucial consideration for covalent drug development, leading to a growing focus on designing lower-reactivity warheads to minimize non-specific covalent binding and reduce the risk of adverse reactions