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In 2021, Doohan and colleagues ( Previous studies have shown that cannabinoids can inhibit various P450 isoforms, but there is evidence that they may also induce P450 enzymes

S-Adenosyl-L-methionine (SAMe) for smoking abstinence: a randomized clinical trial

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Altomare DF, Rotelli MT, Palasciano N

Since our goal was to build a model that improves the detection of negative cases without sacrificing the ability to detect positive cases, we chose to tune our model hyperparameters and perform threshold shifting based on a custom metric that locates the point of highest specificity on the ROC curve for which sensitivity is still 1 (max (specificity/sensitivity) = 1)