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for example, IL-1 can damage endothelial tight junctions, inhibit astrocytic production of Sonic Hedgehog (SHH) signaling, and induce the release of further pro-inflammatory factors, thereby exacerbating neuroinflammation ( levels lead to HPA axis dysfunction and impaired hippocampal-raphe 5-HT pathway function, resulting in depressive-like behaviors (Mazarati et al., 2010)

Another way of measuring the antioxidant response is via the TAC, a parameter that incorporates not just the organisms intrinsic defense mechanisms, but also the antioxidant compounds we ingest as part of our diet 39

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J Pharm Bio Allied Sci 7(Supplement 2) Johri A, Beal MF (2012) Antioxidants in Huntingtons disease

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Some people may not experience any symptoms at all, while others may have an increased susceptibility to certain health problems