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One case report of creatine supplementation has been related to each of the following: atrial fibrillation, dermatitis and acute interstitial nephritis

This led to reduced microglia, proliferation of mitochondria and production of reactive oxygen species, and increased oxygen consumption, but decreased ATP production and overproduction of glutamate

Grigat, S

doi: 10.1038/ng731 73 NguyenQDFaivreSBruyneelERivatCSetoMEndoTet al

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However, the only additional time point at which VPT reached a significant difference between IT and CT was the 9-year follow-up, whereas the rates after 3, 6, and 12 years did not differ between the groups