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The expression and activities of GPX3 are changed in many pathological processes involved in systemic non-neoplastic disorders, such as kidney diseases, cardiovascular diseases, respiratory diseases, metabolic diseases, digestive system diseases, neurological disorders, bone and joint diseases, and other diseases (Figure 3)

Nitric Oxide 25(2):161168 Zhang XW, Feng N, Liu YC, Guo Q, Wang JK, Bai YZ, et al

In tumor-associated cells, tryptophan is catabolized by indoleamine 2,3-dioxygenase (IDO), leading to its depletion and the accumulation of kynurenine, which promotes T cell anergy, enhances Treg generation, and directly suppresses effector T cell responses through aryl hydrocarbon receptor (AhR) signaling

Electroacupuncture promotes microglial M2 polarization in ischemic stroke via annexin A1

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Adjustments are common and expected peptide therapy is precision medicine, not one-size-fits-all