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Results: Significant decreases from baseline were observed for AHK-Cu

An enhanced expression of EMT and metabolism regulators including G6PD and AKR1B1 and TGF1 observed in vitro in carboplatin resistant cell line was confirmed in platinum resistant and relapsed human ovarian tumor samples, compared to chemo nave human tumors

Additional to this pathway, there are other pathways that involve different adaptor proteins, but ultimately lead to the activation of NF- and other inflammatory signaling molecules, such as AP-1 (Yamamoto et al., 2002

Davis Thomas Hollis Frontiers for Young Minds doi 10.3389/frym.2016.00023 67,205 views 3 citations Case Report Published on 16 Jun 2026 Case Report: Allergic reaction following fecal microbiota transplantation in children with autism spectrum disorder: a report of two cases in Pediatric Immunology Zhihui Peng Yuanbing Hu Sheng Wang Chunhua Liu Qi Zhou Shiyu Xie Silin Huang Nan Liu Yanli Wang Frontiers in Pediatrics doi 10.3389/fped.2026.1847568 789 views Case Report Published on 09 Jan 2026 Recurrent coronary artery in-stent restenosis caused by metal allergy: a case report in Coronary Artery Disease Yang Li Zhengbang Dong Qiming Dai Yi Feng Lijuan Chen Genshan Ma Frontiers in Cardiovascular Medicine doi 10.3389/fcvm.2025.1693234 1,810 views Original Research Published on 10 Jun 2021 Alteration of Intestinal Microbiota Composition in Oral Sensitized C3H/HeJ Mice Is Associated With Changes in Dendritic Cells and T Cells in Mesenteric Lymph Nodes in Immunological Tolerance and Regulation Cui Zhou Ling-Ling Chen Rui-Qi Lu Wei-Wei Ma Rong Xiao Frontiers in Immunology doi 10.3389/fimmu.2021.631494 8,370 views 24 citations Original Research Published on 07 Oct 2020 Incidence Rate of Hypersensitivity Reactions to Bee-Venom Acupuncture in Translational Pharmacology Eun-Jung Lee Yo-Chan Ahn Young-Il Kim Min-Seok Oh Yang-Chun Park Chang-Gue Son Frontiers in Pharmacology doi 10.3389/fphar.2020.545555 7,083 views 8 citations Review Published on 28 Jul 2021 The Importance of Metabolism for Immune Homeostasis in Allergic Diseases in Immunological Tolerance and Regulation Juan Rodriguez-Coira Alma Villaseor Elena Izquierdo Mengting Huang Toms Clive Barker-Tejeda Urszula Radzikowska Milena Sokolowska Domingo Barber Frontiers in Immunology doi 10.3389/fimmu.2021.692004 22,282 views 48 citations Case Report Published on 30 Oct 2024 Case Report: Postoperative ascites: allergic reaction to the drainage tube in a 12-year-old patient in Pediatric Surgery Ren-sen Jiang Jing Lao Huan-sheng Wang Miao-bing Wu Bing Wang Jian-yao Wang Frontiers in Surgery doi 10.3389/fsurg.2024.1409673 2,873 views 1 citation Case Report Published on 30 Aug 2024 Epithelioid inflammatory myofibroblastic sarcoma treated with Alectinib: a case report and literature review in Surgical Oncology Xinchun Wu Junxi Zhu Yichao Yan Dongfeng Niu Lin Chen Frontiers in Oncology doi 10.3389/fonc.2024.1412225 3,129 views 2 citations

Thus, clinical trials are currently testing the following drugs in combination with CB-839: nivolumab as a treatment for melanoma, renal cell carcinoma (RCC), and NSCLC (clinicaltrials.gov ID: NCT02771626)