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NRF2, nuclear factor-erythroid 2 related factor 2

This falls slightly below aggressive standalone protocols but within effective ranges, especially considering the synergistic effects of combination therapy

Front Pharmacol 13:1036423

Nuciferine elevates conjugated BA and non-12OH BA levels, downregulates protein levels of FXR, FGF15, FGFR4, and ASBT, and upregulates protein levels of CYP7A1 and CYP27A1, decreases BSH-producing genus, 7-dehydroxylation genus, and increases taurine metabolism-related genus (Sun et al., 2022)

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Before treatment, common concerns include uneven tone, dullness, tanning, and pigmentation patches
