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Since dysregulation of redox-sensitive transcriptional factors (e.g., Nrf2, NF- B, and FoxO) may play an important role in the development of schizophrenia, modulators of the activity of these factors may contribute to the normalization of redox balance

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In the light of excellent performance of BBB crossing strategies for enhanced drug delivery, we will first summarize the structure and different cells contributing to the integrity of BBB (Fig

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