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Clinical presentation and prognostic features in patients with immunotherapy-induced vitiligo-like depigmentation: a monocentric prospective observational study

Hippocampus 22:723736 Mingorance C, Duluc L, Chalopin M, Simard G, Ducluzeau PH, Herrera MD, Alvarez de Sotomayor M, Andriantsitohaina R (2012) Propionyl-l-carnitine corrects metabolic and cardiovascular alterations in diet-induced obese mice and improves liver respiratory chain activity

2016 Chatterjee, R

Defining therapeutic windows and developing sensitive and relevant biomarkers are critical to facilitating potential success in clinical trials

Functional studies in mice determined that while both the T158M and R133C mutations create MECP2 proteins with reduced DNA-binding ability, the T158M mutation also leads to protein instability, likely resulting in the unique and more severe phenotype presentation (Brown et al