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Astrocytes were found to contain a higher amount of cholesterol in their PM than neurons, which was associated with a higher extent of A incorporation into membranes and increased calcium influx into cells (Abramov et al., 2019)

Together, these in vitro observations argue in support of molecular and biological mechanisms underlying the individual variability in the effect of alcohol

First, clinical evidence mostly relies on small-sample, short-follow-up single-center trials, and some preparations are mixed-strain, making it difficult to confirm the independent role of individual Clostridium

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When IgG auto-Abs bind to a cell-surface target, they can activate complement or immune cell-mediated inflammatory responses directed against non-pathogenic tissue [20, 131]