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Cross AL, Hawkes J, Wright HL et al (2020) APPA (apocynin and paeonol) modulates pathological aspects of human neutrophil function, without supressing antimicrobial ability, and inhibits TNF expression and signalling

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While the roles of DNA DSBs, oxidative stress, and chronic inflammation are well understood, a unified framework that incorporates epigenetic regulation, mitochondrial dysfunction, and stromal-immune interactions is still lacking

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