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GSTs play a crucial role in detoxifying the reactive metabolites of methylcholanthrene, a well-known polycyclic aromatic hydrocarbon, by catalyzing its attachment with GSH

10.1016/j.brainres.2008.08.078 33 IshikadoA.MorinoK.NishioY.NakagawaF.MukoseA.SonoY.et al

doi: 10.1039/C2CS35265F

Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma

Knockout mutants for GGT1 show a phenotype of decreased growth and earlysenescence, linked to accumulation of GSSG (Ohkamu-Ohtsu et al., 2007a)
