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Theres no strict limit

14(9): 1048 Kasper S, Dienel A

He was a mild smoker without other cardiovascular risk factors, in particular there was no familial history of any cardiac disease

7-Keto-DHEA Increases Resting Metabolic Rate in Overweight Adults unpublished in J Nutr Biochem, as summarized in LifeExtension.org, referencing evidence of increased basal metabolic rate and thermogenesis in humans, with safe tolerance up to 200 mg/day Life Extension

Store at room temperature and avoid excessive heat

The first-line treatment is to relieve the symptoms with painkiller drugs, such as acetaminophen and naproxen, and other medicines like diphenhydramine, etc