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Symptoms of hypokalemia include fatigue, muscle weakness, constipation, and impaired cardiac contractility with irregular heart rate

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Although several steps in this proposed general mechanism still need detailed confirmation in ex vivo in vitro and in in vivo models through combined metallomic-metabolomic approaches [211,212] and through a systematic physico-chemical study of the involved molecular systems, the collected information allows us to design experimental approaches aimed at verifying the missing steps of the comprehensive model

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