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They can trigger several pro-metastatic signaling cascades, including the NF-B pathway [84], which regulates genes related to cell survival, proliferation, and metastasis, and MAPK pathways that influence cell proliferation, survival, and migration [82]

Nitric oxide synthase and structure-based inhibitor design

Since the response is dose-sensitive and even biphasic, careful studies test a spread of concentrations across several orders of magnitude rather than betting on one number

For gene knockdown study, IPEC-J2 cells were infected with shLacz cloned adenovirus (AdshLacz) or shGPX4 cloned adenovirus (AdshGPX4) or shSELS cloned adenovirus (AdshSELS) at MOI of 50 for 48 h

Tsang CK, Liu Y, Thomas J, Zhang Y, Zheng XF (2014) Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance

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