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According to the National Institutes of Health, even at high levels, B12 isnt toxic and is generally considered safe because your body doesnt store excess amounts

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The timing of food consumption is crucial, as catabolic hormones such as adrenaline are primarily produced in the first part of the day, while anabolic hormones like growth hormone (GH) are predominant in the afternoon and evening

doi: 10.1007/s12011-011-9146-2

10.1007/s00595-007-3706-2 [DOI] [PubMed] [Google Scholar] Nowak K

So getting enough sleep and reducing stress can increase or maintain glutathione levels