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Its progression is closely linked to the activity and stability of GPX4, making the inhibition of lipid peroxidation and the preservation of GPX4 function pivotal targets in ferroptosis-based therapeutic interventions

In this process, GSH is constantly oxidized to GSSG by the enzyme glutathione peroxidase.To maintain the intracellular redox balance, GSH is replenished through the reduction GSSG by glutathione reductase enzyme

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Still, how an increase in GCLC expression alone can increase GCL activity and GSH level cant be easily explained if GCLM is limiting

Funding Acquisition, R.S

doi: 10.1136/ard-2022-222501 [DOI] [PubMed] [Google Scholar] 167