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Cytochrome P450-activated prodrugs

TGF attenuates tumor response to PD-L1 blockade by contributing to exclusion of T cells

the pseudo-first order rate constants for 7a, 9 and 2a are 0.59 0.02, 0.57 0.02, and 0.58 0.03 min 1 , respectively
Disulfide bonds, for example, can form between cysteine residues in a peptide, stabilizing its structure and enhancing its activity

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ROS regulate several signaling pathways involved in regulating drug efflux pumps
