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It was generally believed that the mutation of epigenetic factors was mainly involved in the conversion of HSPCs to pre-LSCs, and involved mainly DNA methyltransferase 3A (DNMT3A) and Tet methyl cytosine dioxygenase 2 (TET2), which made HSCs more prone to leukemogenesis (152)

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Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone

10.1080/13880209.2022.2067572 116 HuangK

Indeed, functional reticularis cells are absent from rodent species commonly used in a laboratory
