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Lysine residues are mono-, di- or trimethylated and arginines are mono-, symmetric di- or asymmetric dimethylated on their -amino groups, and these methyl marks play an important role in chromatin remodelling

2018 August 23

10.1038/nature14506 Nature 75 OSheaR

Key Points: Phase I liver detoxification involves modification of toxic substances through oxidation, reduction, hydrolysis, hydration, and dehalogenation reactions, primarily facilitated by cytochrome p450 enzymes, transforming them into more reactive intermediates

HCV induces transforming growth factor beta1 through activation of endoplasmic reticulum stress and the unfolded protein response