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Effect of graded Nrf2 activation on phase-I and-II drug metabolizing enzymes and transporters in mouse liver

However, presence of reactive oxygen, nitrogen or chlorine species (RO/N/CS) can either directly or indirectly cause a variety of different thiol modifications [6769], which affect enzymatic activities, protein-protein interactions, susceptibility towards other post-translational modifications, protein turnover and/or sub-cellular localizations [16,70,71]

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Superti, F., & Russo, R

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Many reputable veterinary compounding pharmacies can prepare it to appropriate standards