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PD is primarily characterized as a movement disorder, stemming from dopamine depletion in the brain due to the degeneration of dopamine-producing neurons in the substantia nigra (SN), which are crucial for movement coordination

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This results in increased stimulation of anorexigenic POMC/CART neurones and decreased activity of orexigenic NPY/AgRP neurones, profoundly altering appetite signals (Trapp and Brierley 2022)

2025 doi: 10.1001/jamaophthalmol.2024.6058

Curcumin Improves Glucose Tolerance via Stimulation of Glucagon-like Peptide-1 Secretion. Molecular Nutrition & Food Research, vol

If you hit a weight target that is acceptable to you and your labs have improved, you should not feel pressured or need to increase the dose in pursuit of a lower weight
